A General Method for Mapping Tertiary Contacts between Amino Acid Residues in Membrane-Embedded Proteins

Hongbo Yu, Masahiro Kono, Timothy D. McKee, +1

Biochemistry

Targeted Delivery of DNA Using YEE(GalNAcAH)3, a Synthetic Glycopeptide Ligand for the Asialoglycoprotein Receptor

June Rae Merwin, G. Stephen Noell, Wendy Thomas, +5

Bioconjugate Chemistry

Vivo Gene TherapyGene TherapiesGlycosylationBiochemistryG Protein-coupled Receptor +13

Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa

Mark A. Findeis, Frank C. Schroeder, Timothy D. McKee, +8

ACS Chemical Neuroscience

Protein SecretionGlycobiologyAmyloid Precursor ProteinChemical BiologyPharmaceutical Chemistry +19

CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies

Nathan O. Fuller, Antonella Pirone, Berkley A. Lynch, +4

ACS Chemical Neuroscience

Optimization of a Natural Product-Based Class of γ-Secretase Modulators

Jed L. Hubbs, Nathan O. Fuller, Wesley Austin, +8

Journal of Medicinal Chemistry

Triterpene-based γ-Secretase ModulatorsMolecular PharmacologyProtein Secretionγ-Secretase ModulatorsProtein Expression +12

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Bin Ma, Doug Marcotte, Murugan Paramasivam, +10

PLoS ONE

MitophagyApoptosisCell DeathCpd 1Receptor Tyrosine Kinase +14

An improved rhodopsin/EGFP fusion protein for use in the generation of transgenic <i>Xenopus laevis</i>

Shengnan Jin, Timothy D. McKee, Daniel D. Oprian

FEBS Letters

Transgenic Xenopus LaevisMolecular BiologyRho–gfp Fusion ProteinRetinal TherapiesRetina +19

Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

Barbara Tate, Timothy D. McKee, Robyn Loureiro, +10

International Journal of Alzheimer s Disease

Neurochemical BiomarkersPeptide ScienceAlzheimer's DiseaseAmyloid PlaquesProtein Folding +16

Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models

Robyn Loureiro, Jo Ann Dumin, Timothy D. McKee, +8

Alzheimer s Research & Therapy

Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside

Nathan O. Fuller, Jed L. Hubbs, Wesley Austin, +8

ACS Medicinal Chemistry Letters

Protein SecretionBioorganic ChemistryGlycobiologyNew SeriesChemical Biology +18