Blockade of N‐type Ca²⁺ current by cilnidipine (FRC‐8653) in acutely dissociated rat sympathetic neurones

Hisayuki Uneyama, Akira Takahara, Hideki Dohmoto, +3

British Journal of Pharmacology

Prolonged Inhibition of Vascular Contraction and Calcium Influx by the Novel 1,4-Dihydropyridine Calcium Antagonist Cinaldipine (FRC-8653).

Ryota Yoshimoto, Hideki Dohmoto, Kaoru Yamada, +1

The Japanese Journal of Pharmacology

Molecular PharmacologyHypertensionHeart FailureCalcium InfluxMedicine +11

Cilnidipine Attenuates Renal Nerve Stimulation-Induced Renal Vasoconstriction and Antinatriuresis in Anesthetized Dogs.

Akira Takahara, Hideki Dohmoto, Hiroaki Hisa, +2

The Japanese Journal of Pharmacology

In Vitro and ex Vivo Ca-Antagonistic Effect of 2-Methoxyethyl(E)-3-phenyl-2-propen-1-yl(.+-.)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate (FRC-8653), a New Dihydropyridine Derivative.

Hiroyuki Iida, Kenro Ikeda, Yutaka Hayashi, +4

Journal of Pharmacobio-Dynamics

Pharmaceutical SciencePharmacotherapyCardiovascular ToxicityExperimental PharmacologyPharmaceutical Chemistry +16

Effects of AH-1058, a New Antiarrhythmic Drug, on Experimental Arrhythmias and Cardiac Membrane Currents

Akira Takahara, Hisayuki Uneyama, Noriko Sasaki, +6

Journal of Cardiovascular Pharmacology

Cardiac MuscleHeart FailureCardiovascular PharmacologyPharmacotherapyWhereas Disopyramide +15

Effects of a dual L/N-type Ca2+ channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs

Tomoyuki Konda, Akira Takahara, Kazutoshi Maeda, +2

European Journal of Pharmacology

Anesthetized DogsAnesthetic PharmacologyNeurophysiologyNeuromuscular BlockadePhysiology +12

Effects of a New Dihydropyridine Derivative, FRC-8653, on Blood Pressure in Conscious Spontaneously Hypertensive Rats.

Ryota Yoshimoto, Hideki Dohmoto, Masahiro Hosono, +4

Journal of Pharmacobio-Dynamics

Cardiovascular action of a cardioselective Ca2+channel blocker AH-1058 in conscious dogs assessed by telemetry

Akira Takahara, Hideki Dohmoto, Ryota Yoshimoto, +2

European Journal of Pharmacology

Cardiovascular DiseasePhysiologyCardiovascular ActionElectrophysiologyCardiovascular Physiology +5

Antiarrhythmic and cardiohemodynamic effects of a novel Ca2+ channel blocker, AH-1058, assessed in canine arrhythmia models

Akira Takahara, Atsushi Sugiyama, Hideki Dohmoto, +2

European Journal of Pharmacology

Cardiac MuscleElectrophysiological EvaluationCardiovascular DiseaseCardiohemodynamic EffectsMedicine +9