Umbilical cord blood–derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

Claudio G. Brunstein, Jeffrey S. Miller, David H. McKenna, +14

Blood

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (T _regs ) with Minimal Loss of in Vivo Functional Activity

Keli L. Hippen, Sarah C. Merkel, Dawn K. Schirm, +13

Science Translational Medicine

Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft

John E. Wagner, Claudio G. Brunstein, Anthony E. Boitano, +9

Cell stem cell

Regenerative MedicineDevelopmental BiologyMedicineStem Cell MobilizationStem Cell Transplantation +10

Good manufacturing practices production of natural killer cells for immunotherapy: a six‐year single‐institution experience

David H. McKenna, Darin Sumstad, Nancy Bostrom, +9

Transfusion

First-in-human phase 1 trial of induced regulatory T cells for graft-versus-host disease prophylaxis in HLA-matched siblings

Margaret L. MacMillan, Keli L. Hippen, David H. McKenna, +10

Blood Advances

Clinical mesenchymal stromal cell products undergo functional changes in response to freezing

Kathryn Pollock, Darin Sumstad, Diane Kadidlo, +2

Cytotherapy

Regenerative MedicineCell TherapyMedicineStem Cell ResearchStem-cell Therapy +5

A multicenter comparison study between the Endosafe® PTS™ rapid-release testing system and traditional methods for detecting endotoxin in cell-therapy products

Adrian P. Gee, Darin Sumstad, Joanna Stanson, +13

Cytotherapy

Microbial ToxinEndosafe® Pts™ Rapid-releaseEngineeringAllergyTraditional Methods +11

Optimization of cGMP purification and expansion of umbilical cord blood–derived T-regulatory cells in support of first-in-human clinical trials

David H. McKenna, Darin Sumstad, Diane Kadidlo, +13

Cytotherapy

Gene TherapiesCgmp PurificationUmbilical CordCell TherapyT-regulatory Cell +10

Complement Fragment 3a Priming of Umbilical Cord Blood Progenitors: Safety Profile

Claudio G. Brunstein, David H. McKenna, Todd E. DeFor, +6

Biology of Blood and Marrow Transplantation

Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial

Emil Lou, Modassir S Choudhry, Timothy K. Starr, +30

The Lancet Oncology

Cancer ImmunosurveillanceMedicineImmunologyColorectal CancerMetastatic Colorectal Cancer +6