Survey of variation in human transcription factors reveals prevalent DNA binding changes

Luis Barrera, Anastasia Vedenko, Jesse V. Kurland, +19

Science

GeneticsGenetic EpidemiologyGenomic MechanismMolecular BiologyGenomics +22

An Internal Disulfide Locks a Misfolded Aggregation-prone Intermediate in Cataract-linked Mutants of Human γD-Crystallin

Eugene Serebryany, Jaie Woodard, Bharat V. Adkar, +3

Journal of Biological Chemistry

EngineeringProtein AssemblyAmyloid AggregationMolecular BiologyHuman γD-crystallin +20

Electrically Induced Conformational Change of Peptides on Metallic Nanosurfaces

Yi Chen, Eduardo R. Cruz-Chú, Jaie Woodard, +3

ACS Nano

EngineeringPeptide EngineeringNanostructured SurfaceSurface-enhanced Raman ScatteringBiomedical Engineering +14

Thermal Stabilization of Dihydrofolate Reductase Using Monte Carlo Unfolding Simulations and Its Functional Consequences

Jian Tian, Jaie Woodard, Andrew Whitney, +1

PLoS Computational Biology

Solvation and Hydrogen Bonding in Alanine- and Glycine-Containing Dipeptides Probed Using Solution- and Solid-State NMR Spectroscopy

Manasi Bhate, Jaie Woodard, Manish Mehta

Journal of the American Chemical Society

ADDRESS: A Database of Disease-associated Human Variants Incorporating Protein Structure and Folding Stabilities

Jaie Woodard, Chengxin Zhang, Yang Zhang

Journal of Molecular Biology

Allelic VariantFolding StabilitiesGeneticsComputational BiologyMolecular Biology +6

Topology of Folded Molecular Chains: From Single Biomolecules to Engineered Origami

Barbara Scalvini, Vahid Sheikhhassani, Jaie Woodard, +4

Trends in Chemistry

Dna NanotechnologyEngineered OrigamiEngineeringFolded Molecular ChainsProtein Folding +11

A Circuit Topology Approach to Categorizing Changes in Biomolecular Structure

Otto Schullian, Jaie Woodard, Arash Tirandaz, +1

Frontiers in Physics

Intramolecular Diffusion in α-Synuclein: It Depends on How You Measure It

Jaie Woodard, Kinshuk Raj Srivastava, Gil Rahamim, +7

Biophysical Journal

Diffusion ProcessNeurologyNeuroscienceMedicineBiophysics +1

Metabolic response to point mutations reveals principles of modulation of <i>in vivo</i> enzyme activity and phenotype

Sanchari Bhattacharyya, Shimon Bershtein, Bharat V. Adkar, +2

Molecular Systems Biology

Dhfr ActivityGeneticsMolecular BiologyFilamentous PhenotypeMetabolic Network +14