Concepedia

W. Edward Martucci

WE

Statistics

Publications

5

Citations

77

H-Index

5

Active since

2007

Affiliations

Yale University(Current)

W. Edward Martucci is an author at Yale University specializing in enzyme function, catalytic mechanisms, and structural biology.

Publications per year

2007–2013

5

Publications

5

Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein–protein interaction in <i>C. hominis</i> thymidylate synthase-dihydrofolate reductase (TS-DHFR)

W. Edward Martucci, Johanna M. Rodriguez, Melissa A. Vargo et al. · MedChemComm · 2013 · 19 citations · Full text

, , +17

Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen

W. Edward Martucci, Marina Udier–Blagović, Chloé E. Atreya et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 19 citations · Full text

, , +8

Nonconserved Residues Ala287 and Ser290 of the <i>Cryptosporidium hominis</i> Thymidylate Synthase Domain Facilitate Its Rapid Rate of Catalysis<sup>,</sup>

Lanxuan Doan, W. Edward Martucci, Melissa A. Vargo et al. · Biochemistry · 2007 · 18 citations

, , +17

Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS–DHFR from <i>Cryptosporidium hominis</i>

Melissa A. Vargo, W. Edward Martucci, Karen S. Anderson · Biochemical Journal · 2008 · 11 citations · Full text

, , +16

Explaining an Unusually Fast Parasitic Enzyme: Folate Tail-Binding Residues Dictate Substrate Positioning and Catalysis in <i>Cryptosporidium hominis</i> Thymidylate Synthase

W. Edward Martucci, Melissa A. Vargo, Karen S. Anderson · Biochemistry · 2008 · 10 citations · Full text

, , +17

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