Florence Domagala

Rhein Inhibits Interleukin-1β-Induced Activation of MEK/ERK Pathway and DNA Binding of NF-κB and AP-1 in Chondrocytes Cultured in Hypoxia: A Potential Mechanism for Its Disease-Modifying Effect in Osteoarthritis

Grégoire Martin, Patrick Bogdanowicz, Florence Domagala et al. · Inflammation · 2003 · 83 citations · Full text

Medicine, Immunology, Pharmacology +16

Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+-ATPase in vitro and in vivo

Jai Moo Shin, M. Homerin, Florence Domagala et al. · Biochemical Pharmacology · 2006 · 60 citations

Medicine, Pharmacology, Pharmacotherapy +13

Inhibition of interleukin-1beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1: potential mechanism for Diacerein effects in osteoarthritis.

Florence Domagala, Grégoire Martin, Patrick Bogdanowicz et al. · PubMed · 2006 · 45 citations

Life Sciences, Cell Biology, Immunology +15

Rhein, a diacerhein-derived metabolite, modulates the expression of matrix degrading enzymes and the cell proliferation of articular chondrocytes by inhibiting ERK and JNK-AP-1 dependent pathways.

Florence Legendre, Patrick Bogdanowicz, Grégoire Martin et al. · PubMed · 2008 · 41 citations

Life Sciences, Biochemistry, Cell Biology +17

Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis

Florence Legendre, A.J. Heuze, K. Boukerrouche et al. · Scandinavian Journal of Rheumatology · 2009 · 40 citations

Medicine, Medicinal Chemistry, Pharmacology +12