CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

Daniel Rosenblum, Anna Gutkin, Ranit Kedmi, +9

Science Advances

The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

Ranit Kedmi, Noa Ben-Arie, Dan Peer

Biomaterials

InflammationNanomedicineToll-like ReceptorsEngineeringAllergy +8

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

Dan Peer, Eun Jeong Park, Yoshiyuki Morishita, +2

Science

Nanoparticle Hydrophobicity Dictates Immune Response

Daniel F. Moyano, Meir Goldsmith, David J. Solfiell, +4

Journal of the American Chemical Society

NanoparticlesNanomedicineCross-protectionEngineeringNanobiotechnology +10

Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions

Thomas J. Anchordoquy, Yechezkel Barenholz, Diana Boraschi, +17

ACS Nano

NanoparticlesEngineeringBiomedical EngineeringTumor BiologyNanomedicine +15

Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

Nuphar Veiga, Meir Goldsmith, Yasmin Granot, +5

Nature Communications

Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1

Dan Peer, Pengcheng Zhu, Christopher V. Carman, +2

Proceedings of the National Academy of Sciences

Autoimmune DiseaseMedicineImmunoengineeringImmunologyGene Expression +13

Hyaluronan-coated nanoparticles: The influence of the molecular weight on CD44-hyaluronan interactions and on the immune response

Shoshy Mizrahy, Sabina Rebe Raz, Martin Hasgaard, +8

Journal of Controlled Release

NanoparticlesEngineeringNanomaterialsHyaluronan-coated NanoparticlesImmunology +9

Loading mitomycin C inside long circulating hyaluronan targeted nano‐liposomes increases its antitumor activity in three mice tumor models

Dan Peer, Rimona Margalit

International Journal of Cancer

Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery

Sara S. Nogueira, Anne Schlegel, Konrad Maxeiner, +10

ACS Applied Nano Materials

NanoparticlesNanomedicineEngineeringPolymer-drug ConjugatePolysarcosine-functionalized Lipid Nanoparticles +10