SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Peter Halfmann, Shun Iida, Kiyoko Iwatsuki‐Horimoto, +80

Nature

SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

Jiří Zahradník, Shir Marciano, Maya Shemesh, +15

Nature Microbiology

Vitro EvolutionViral EvolutionEngineeringMedicineAntiviral Drug Development +10

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

Kizzmekia S. Corbett, Martha Nason, Britta Flach, +59

Science

VaccinationVaccinologyMrna-1273 VaccineViral ReplicationVaccine Development +13

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

Kevin O. Saunders, Esther Lee, Robert Parks, +46

Nature

VaccinationAntibody VaccineVaccine DevelopmentVaccine TargetImmunology +3

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization

Katie Paul Friedman, Matthew Gagné, Lit‐Hsin Loo, +19

Toxicological Sciences

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

Matthew Gagné, Juan I. Moliva, Kathryn E. Foulds, +72

Cell

VaccinationVaccine DevelopmentVaccine ResearchHumoral ResponseImmunology +7

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant

Venkata-Viswanadh Edara, Kelly E. Manning, Madison Ellis, +25

Cell Reports Medicine

Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine–boosted nonhuman primates

Kizzmekia S. Corbett, Matthew Gagné, Danielle A. Wagner, +61

Science

Infection and vaccine-induced neutralizing antibody responses to the SARS-CoV-2 B.1.617.1 variant

Venkata Viswanadh Edara, Lilin Lai, Malaya K. Sahoo, +21

The SARS-CoV-2 B.1.1.529 Omicron virus causes attenuated infection and disease in mice and hamsters

Michael Diamond, Peter Halfmann, Tadashi Maemura, +62