GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment

Zhiming Suo, April Cox, Nicholas L. Bartelli, +4

Neurobiology of Aging

Alzheimer's DiseaseMemory ImpairmentDementiaGrk5 DeficiencyEarly Alzheimer-like Pathology +9

Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

Kevin W. Hunt, Adam W. Cook, Ryan J. Watts, +23

Journal of Medicinal Chemistry

Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice

Supriti Samantaray, Varduhi H. Knaryan, Donald C. Shields, +3

Molecular Neurobiology

Gait DynamicsSpinal Cord InjuryHealth SciencesSpinal Cord NeurodegenerationMedicine +12

ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models.

Richard Woessner, Brian Tunquist, Christine Lemieux, +8

PubMed

Nanoparticle Estrogen in Rat Spinal Cord Injury Elicits Rapid Anti-Inflammatory Effects in Plasma, Cerebrospinal Fluid, and Tissue

April Cox, Abhay Varma, John Barry, +2

Journal of Neurotrauma

NanotherapeuticsEngineeringSpinal Cord TissueBiomedical EngineeringInjured Spinal Cord +18

Targeting Enolase in Reducing Secondary Damage in Acute Spinal Cord Injury in Rats

Azizul Haque, Mollie Capone, Denise Matzelle, +2

Neurochemical Research

Spinal Cord InjuryMedicineSpinal TraumaNeuropathic PainNeuropharmacology +6

Discovery of 7-Tetrahydropyran-2-yl Chromans: β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β-Protein (Aβ) in the Central Nervous System

Allen A. Thomas, Kevin W. Hunt, Matthew Volgraf, +24

Journal of Medicinal Chemistry

7-Tetrahydropyran-2-yl ChromansPeptide ScienceNeurochemical BiomarkersPharmaceutical ChemistryMolecular Pharmacology +18

Discovery of a Novel Class of Imidazo[1,2-<i>a</i>]Pyridines with Potent PDGFR Activity and Oral Bioavailability

Erik J. Hicken, Fred P. Marmsater, Mark Munson, +18

ACS Medicinal Chemistry Letters

Pharmaceutical ScienceOral BioavailabilitySilico ConstructionOrganic ChemistryPharmacotherapy +18

Nanoparticle-Based Estrogen Delivery to Spinal Cord Injury Site Reduces Local Parenchymal Destruction and Improves Functional Recovery

April Cox, Mollie Capone, Denise Matzelle, +6

Journal of Neurotrauma

Protective Effects of Estrogen via Nanoparticle Delivery to Attenuate Myelin Loss and Neuronal Death after Spinal Cord Injury

Azizul Haque, Kelsey P. Drasites, April Cox, +9

Neurochemical Research

NanomedicineNeuroregenerationSpinal Cord InjuryNanoparticle DeliverySpinal Trauma +6