Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

Jae-Hwan Kim, Jennifer P. Moody, Christina K. Edgerly, +5

Human Molecular Genetics

Neurodegenerative DiseasesMitochondrial LossMitochondrial FunctionMitochondrial DysfunctionMitochondrial Biogenesis +12

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

Mathilde Faideau, Jae-Hwan Kim, Kerry Cormier, +10

Human Molecular Genetics

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

Edward C. Stack, James K. Kubilus, Karen Smith, +6

The Journal of Comparative Neurology

Combination therapy with Coenzyme Q₁₀ and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s Diseases

Lichuan Yang, Noel Y. Calingasan, Elizabeth Wille, +4

Journal of Neurochemistry

Synaptic SignalingSocial Sciences3-Np Rat ModelOxidative StressNeurobiology Of Disease +14

The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity

Xin Wang, Ana C. Sirianni, Zhijuan Pei, +12

Journal of Neuroscience

Cell DeathType 1Degenerative PathologyCell SignalingNeuropharmacology +14

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice

Junghee Lee, Béla Kosaras, Steve J. Del Signore, +5

Acta Neuropathologica

Neurodegenerative DiseasesMitochondrial FunctionLipid PeroxidationPhysiologyExperimental Neuropathology +9

Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile

Alpaslan Dedeoglu, Ji‐Kyung Choi, Kerry Cormier, +2

Brain Research

Neuroimaging BiomarkersNeurochemical ProfileAlzheimer's DiseaseBiochemistryDementia +9

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

Alpaslan Dedeoglu, Kerry Cormier, Sandra M. Payton, +10

Experimental Gerontology

Alzheimer's DiseasePreliminary StudiesBiochemistryNatural SciencesMetalloprotein +4

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

Yi Zhang, Anna Cook, Jin-Ho Kim, +11

Neurobiology of Disease

Amyotrophic Lateral SclerosisAlzheimer's DiseaseCell DeathNeuroprotectionNeuroscience +9

Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice

Karen Smith, Samantha Matson, Wayne R. Matson, +6

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

PharmacologyExperimental TherapeuticPharmacotherapyNeurologyMedicine +4