Zachary J. DeBruine

Crystal structure of the Frizzled 4 receptor in a ligand-free state

Shifan Yang, Yiran Wu, Ting-Hai Xu et al. · Nature · 2018 · 120 citations

Natural Sciences, Biochemistry, Chemistry +16

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

Zachary J. DeBruine, Jiyuan Ke, Kaleeckal G. Harikumar et al. · Genes & Development · 2017 · 68 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Fast and interpretable non-negative matrix factorization for atlas-scale single cell data

Zachary J. DeBruine, J. Andrew Pospisilik, Timothy J. Triche · bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 60 citations · Full text

Life Sciences, Bioinformatics, Biostatistics +16

Independent phenotypic plasticity axes define distinct obesity sub-types

Chih-Hsiang Yang, Luca Fagnocchi, Stefanos Apostle et al. · Nature Metabolism · 2022 · 40 citations · Full text

Life Sciences, Endocrinology, Genetics +17

Nuclear localization signal sequence is required for VACM-1/CUL5-dependent regulation of cellular growth

Angelica N. Willis, Shirley Dean, Joe Habbouche et al. · Cell and Tissue Research · 2016 · 18 citations

Life Sciences, Cell Biology, Molecular Biology +12