Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants

Simona Salati, Elena Genovese, Chiara Carretta, +16

Scientific Reports

Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in<i>JAK2V617F</i>mutated cells through PP2A/CIP2A axis

Niccolò Bartalucci, Laura Calabresi, Manjola Balliu, +6

Oncotarget

RETRACTED: <scp>HDAC</scp> ‐inhibitor (S)‐8 disrupts <scp>HDAC</scp> 6‐ <scp>PP</scp> 1 complex prompting A375 melanoma cell growth arrest and apoptosis

Manjola Balliu, Luca Guandalini, María Novella Romanelli, +2

Journal of Cellular and Molecular Medicine

Effectiveness of the Histone Deacetylase Inhibitor (S)-2 against LNCaP and PC3 Human Prostate Cancer Cells

Anna Laurenzana, Manjola Balliu, Cristina Cellai, +2

PLoS ONE

Histone ModificationsChemoprevention StrategyHistone Deacetylase InhibitorApoptosisCell Death +17

Clinical impact of mutated <scp>JAK2</scp> allele burden reduction in polycythemia vera and essential thrombocythemia

Paola Guglielmelli, Barbara Mora, Francesca Gesullo, +16

American Journal of Hematology

Inhibition of ERK1/2 signaling prevents bone marrow fibrosis by reducing osteopontin plasma levels in a myelofibrosis mouse model

Elisa Bianchi, Sebastiano Rontauroli, Lara Tavernari, +22

Leukemia

Mechanistic insight into WEB-2170-induced apoptosis in human acute myelogenous leukemia cells: The crucial role of PTEN

Cristina Cellai, Anna Laurenzana, Elisa Bianchi, +13

Experimental Hematology

Mixed-phenotype Acute LeukemiaApoptosisMechanistic InsightWeb-2170-induced ApoptosisMolecular Biology +7

Activated IL-6 signaling contributes to the pathogenesis of, and is a novel therapeutic target for, <i>CALR</i>-mutated MPNs

Manjola Balliu, Laura Calabresi, Niccolò Bartalucci, +6

Blood Advances

Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring

Luca Guandalini, Manjola Balliu, Cristina Cellai, +12

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryPreliminary EvaluationMedicineDrug Discovery +9

The Response to Oxidative Damage Correlates with Driver Mutations and Clinical Outcome in Patients with Myelofibrosis

Elena Genovese, Margherita Mirabile, Sebastiano Rontauroli, +23

Antioxidants