Kyle A. Edgar

Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome

Annette L. Parks, Kevin R Cook, Marcia Belvin et al. · Nature Genetics · 2004 · 774 citations

Life Sciences, Genetics, Molecular Genetics +15

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

Ruihuan Chen, Merry Nishimura, Stephanie M. Bumbaca et al. · Cancer Cell · 2010 · 542 citations · Full text

Medicine, Cancer Biology, Oncology +12

Oncogenic ERBB3 Mutations in Human Cancers

Bijay S. Jaiswal, Noelyn M. Kljavin, Eric Stawiski et al. · Cancer Cell · 2013 · 347 citations · Full text

Medicine, Genetics, Oncology +14

GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway

Jeffrey J. Wallin, Kyle A. Edgar, Jane Guan et al. · Molecular Cancer Therapeutics · 2011 · 228 citations

Medicine, Oncology, Pharmacology +16

Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1<i>H</i>-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-<i>d</i>][1,4]oxazepin-9-yl]-1<i>H</i>-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

Chudi Ndubaku, Timothy P. Heffron, Steven T. Staben et al. · Journal of Medicinal Chemistry · 2013 · 176 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13