A Novel HER3-Targeting Antibody–Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization

Yuuri Hashimoto, Kumiko Koyama, Yasuki Kamai, +20

Clinical Cancer Research

U3-1402, a Novel HER3-Targeting Antibody–Drug Conjugate, for the Treatment of Colorectal Cancer

Shigehiro Koganemaru, Yasutoshi Kuboki, Yoshikatsu Koga, +8

Molecular Cancer Therapeutics

An HER3-targeting antibody–drug conjugate incorporating a DNA topoisomerase I inhibitor U3-1402 conquers EGFR tyrosine kinase inhibitor-resistant NSCLC

Kimio Yonesaka, Naoki Takegawa, Satomi Watanabe, +9

Oncogene

Drug TargetingNovel TherapyImmunologyHer3-targeting Antibody–drug ConjugateImmunotherapeutics +7

U3-1402 sensitizes HER3-expressing tumors to PD-1 blockade by immune activation

Koji Haratani, Kimio Yonesaka, Shiki Takamura, +14

Journal of Clinical Investigation

Impaired osteoclast differentiation and function and mild osteopetrosis development in Siglec-15-deficient mice

Yoshiharu Hiruma, Naoyuki Maeda, Akiko Okada, +4

Bone

MechanobiologySclerostinDevelopmental BiologyBone Morphogenic ProteinMild Osteopetrosis Development +7

Effects of HMG-CoA reductase inhibitors on skeletal muscles of rabbits

Masaharu Fukami, Naoyuki Maeda, Junichiroh Fukushige, +4

Research in Experimental Medicine

Animal PhysiologyHmg-coa Reductase InhibitorsMuscle FunctionMuscle InjuryBiochemistry +7

ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice

Naoki Terasaka, Atsuhiro Miyazaki, Naomi Kasanuki, +7

Atherosclerosis

InflammationAtherosclerotic LesionsOxysterolBiochemistryCardiovascular Disease +9

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model

Takeshi Jimbo, Mana Hatanaka, Takahiro Komatsu, +8

Oncotarget

Accurate determination of tissue steroid hormones, precursors and conjugates in adult male rat

Naoyuki Maeda, Emi Tanaka, T. Suzuki, +5

The Journal of Biochemistry

Expression of a Mucin-like Glycoprotein Produced by Ocular Surface Epithelium in Normal and Keratinized Cells

Hitoshi Watanabe, Naoyuki Maeda, AKIRA KIRITOSHI, +2

American Journal of Ophthalmology

Mucin-like Glycoprotein ProducedOphthalmologyCorneal DystrophyKeratinized CellsOcular Tissue +9