Hiroyuki Kakinuma

(1<i>S</i>)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-<scp>d</scp>-glucitol (TS-071) is a Potent, Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for Type 2 Diabetes Treatment

Hiroyuki Kakinuma, Takahiro Oi, Yuko Hashimoto-Tsuchiya et al. · Journal of Medicinal Chemistry · 2010 · 158 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Development of a Method for Evaluating Drug-Likeness and Ease of Synthesis Using a Data Set in Which Compounds Are Assigned Scores Based on Chemists' Intuition

Yuji Takaoka, Yutaka Endo, Susumu Yamanobe et al. · Journal of Chemical Information and Computer Sciences · 2003 · 96 citations

Pharmacy, Chemistry, Medicinal Chemistry +17

Pyrazole and Isoxazole Derivatives as New, Potent, and Selective 20-Hydroxy-5,8,11,14-eicosatetraenoic Acid Synthase Inhibitors

Toshio Nakamura, Masakazu Sato, Hiroyuki Kakinuma et al. · Journal of Medicinal Chemistry · 2003 · 78 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors

Toshio Nakamura, Hiroyuki Kakinuma, Hiroki Umemiya et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 68 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

In vitro abzyme evolution to optimize antibody recognition for catalysis

Naoko Takahashi, Hiroyuki Kakinuma, Lidong Liu et al. · Nature Biotechnology · 2001 · 65 citations

Pharmacy, Biochemistry, Molecular Biology +14