Robert Espina

Metabolism of Capsaicin by Cytochrome P450 Produces Novel Dehydrogenated Metabolites and Decreases Cytotoxicity to Lung and Liver Cells

Christopher A. Reilly, William J. Ehlhardt, David A. Jackson et al. · Chemical Research in Toxicology · 2003 · 131 citations

Medicine, Pharmacology, Toxicology +17

Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

Robert Espina, Linning Yu, Jianyao Wang et al. · Chemical Research in Toxicology · 2008 · 113 citations

Life Sciences, Biochemistry, Toxicology +17

Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

Karthick Vishwanathan, Kathlene Babalola, Jack Wang et al. · Chemical Research in Toxicology · 2008 · 99 citations

Life Sciences, Pharmacokinetics, Pharmacology +17

Characterization of HKI-272 Covalent Binding to Human Serum Albumin

Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton et al. · Drug Metabolism and Disposition · 2010 · 61 citations

Pharmacy, Biochemistry, Molecular Biology +16

Disposition of Glutathione Conjugates in Rats by a Novel Glutamic Acid Pathway: Characterization of Unique Peptide Conjugates by Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/NMR

Abdul Mutlib, John P. Shockcor, Robert Espina et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 38 citations

Medicine, Biochemistry, Pharmacology +16