Akiyoshi Shimaya

Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db Mice

Takeyuki Nagashima, Nobuharu Shigematsu, Riyo Maruki et al. · Molecular Pharmacology · 2010 · 272 citations

Antagonism of peroxisome proliferator-activated receptor γ prevents high-fat diet-induced obesity in vivo

Ryosuke Nakano, Eiji Kurosaki, S. Yoshida et al. · Biochemical Pharmacology · 2006 · 68 citations

Obesity, Metabolic Syndrome, Energy Homeostasis +11

Purification and characterization of lysosomal H(+)-ATPase. An anion-sensitive v-type H(+)-ATPase from rat liver lysosomes.

Kunizo Arai, Akiyoshi Shimaya, N. Hiratani et al. · Journal of Biological Chemistry · 1993 · 61 citations · Full text

Rat Liver Lysosomes, Cellular Enzymology, Biochemistry +15

Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist

Hirotsugu Tanaka, Akiyoshi Shimaya, Tetsuo Kiso et al. · Life Sciences · 2011 · 44 citations

Enhanced Insulin Secretion, Medicine, Physiology +9

Novel GPR40 agonist AS2575959 exhibits glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion

Hirotsugu Tanaka, S. Yoshida, Hideaki Minoura et al. · Life Sciences · 2013 · 40 citations

Glucose Metabolism Improvement, Metabolic Syndrome, Synergistic Effect +13