Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression

Qiaohui Lu, Akihiro Mouri, Yang Yang, +8

Behavioural Brain Research

PsychopathologyStress HormonePsychiatryBehavioral NeuroscienceStress +13

Heat-sterilized Bifidobacterium breve prevents depression-like behavior and interleukin-1β expression in mice exposed to chronic social defeat stress

Aika Kosuge, Kazuo Kunisawa, Satoshi Arai, +10

Brain Behavior and Immunity

InflammationPsychoneuroimmunologyStress HormoneStressHeat-sterilized Bifidobacterium Breve +9

Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling

Yasuko Yamamoto, Wakana Yamasuge, Shinjiro Imai, +6

Scientific Reports

Betaine attenuates memory impairment after water-immersion restraint stress and is regulated by the GABAergic neuronal system in the hippocampus

Kazuo Kunisawa, Kiwamu Kido, Natsuki Nakashima, +3

European Journal of Pharmacology

Neurobiological MechanismNeuropsychologyMemory ImpairmentNeurophysiologyMedicine +9

Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues

Yukihiro Yoshida, Hidetsugu Fujigaki, Koichi Kato, +8

Scientific Reports

Indoleamine 2,3‐dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma

Wakana Yamasuge, Yasuko Yamamoto, Hidetsugu Fujigaki, +6

Cancer Science

Betaine prevents homocysteine-induced memory impairment via matrix metalloproteinase-9 in the frontal cortex

Kazuo Kunisawa, Natsuki Nakashima, Masaki Nagao, +3

Behavioural Brain Research

Alzheimer's DiseaseBiochemistryNeurochemical BiomarkersMatrix Metalloproteinase-9Neurology +6

Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid

Yuko Mori, Akihiro Mouri, Kazuo Kunisawa, +14

Behavioural Brain Research

Molecular PharmacologyEnhanced AntagonismMedicinePhysiologyBehavioral Pharmacology +9

Prefrontal cortex miR‐874‐3p prevents lipopolysaccharide‐induced depression‐like behavior through inhibition of indoleamine 2,3‐dioxygenase 1 expression in mice

Willy Jaya Suento, Kazuo Kunisawa, Bolati Wulaer, +9

Journal of Neurochemistry

PsychopharmacologyLocomotor ActivitySocial SciencesNeuroinflammationDepression‐like Behavior +22

Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus

Bolati Wulaer, Kazuo Kunisawa, Kazuhiro Hada, +11

Journal of Neurochemistry