Impact of linker length on the activity of PROTACs

Kedra Cyrus, Marie Wehenkel, Eunyoung Choi, +4

Molecular BioSystems

Molecular RegulationEstrogen ReceptorMolecular BiologyCytoskeletonPeptide Science +21

LMP2-Specific Inhibitors: Chemical Genetic Tools for Proteasome Biology

Yik Khuan Ho, Paola Bargagna‐Mohan, Marie Wehenkel, +2

Chemistry & Biology

Protein FunctionNatural SciencesLmp2-specific InhibitorsMolecular BiologyProteomics +1

Structure-Based Design of β1i or β5i Specific Inhibitors of Human Immunoproteasomes

Gerjan de Bruin, E.M. Huber, Bo‐Tao Xin, +9

Journal of Medicinal Chemistry

Proteasome InhibitorsDrug TargetHuman ImmunoproteasomesMolecular BiologyPeptide Science +21

Targeted Degradation of the Aryl Hydrocarbon Receptor by the PROTAC Approach: A Useful Chemical Genetic Tool

Hyosung Lee, Dinesh Puppala, Eun‐Young Choi, +2

ChemBioChem

Bioorganic ChemistryMolecular BiologyChemical BiologyEnzymatic ModificationBiochemical Genetics +16

Jostling for Position: Optimizing Linker Location in the Design of Estrogen Receptor‐Targeting PROTACs

Kedra Cyrus, Marie Wehenkel, Eun‐Young Choi, +3

ChemMedChem

Breast OncologyEngineeringChemoprevention StrategyEstrogen ReceptorMolecular Biology +20

A Cancer-Specific Variant of the <i>SLCO1B3</i> Gene Encodes a Novel Human Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Localized Mainly in the Cytoplasm of Colon and Pancreatic Cancer Cells

Nilay Thakkar, Kyungbo Kim, Eun Ryoung Jang, +6

Molecular Pharmaceutics

Molecular BiologyPathologyPancreatic Cancer CellsCancer BiologyTumor Biology +15

Use of PROTACS as molecular probes of angiogenesis

Paola Bargagna‐Mohan, Sun‐Hee Baek, Hyosung Lee, +2

Bioorganic & Medicinal Chemistry Letters

AngiogenesisVascular BiologyNeovascularizationMedicineCell Biology +2

Degradation of target protein in living cells by small-molecule proteolysis inducer

Dong Zhang, Sun-Hee Baek, Abby Ho, +1

Bioorganic & Medicinal Chemistry Letters

Protein FunctionSignal TransductionProtein ExpressionBiochemistryMedicine +9

Two‐Headed PROTAC: An Effective New Tool for Targeted Protein Degradation

Kedra Cyrus, Marie Wehenkel, Eun‐Young Choi, +2

ChemBioChem

Molecular Basis of the Selectivity of the Immunoproteasome Catalytic Subunit LMP2-Specific Inhibitor Revealed by Molecular Modeling and Dynamics Simulations

Beilei Lei, Mohamed Diwan M. Abdul Hameed, Adel Hamza, +5

The Journal of Physical Chemistry B

Protein AssemblyDynamics SimulationsMolecular BiologyPeptide ScienceAnalytical Ultracentrifugation +20