Akiyasu Kouketsu

Novel Inhibitors of Human Histone Deacetylases:  Design, Synthesis, Enzyme Inhibition, and Cancer Cell Growth Inhibition of SAHA-Based Non-hydroxamates

Takayoshi Suzuki, Yuki Nagano, Akiyasu Kouketsu et al. · Journal of Medicinal Chemistry · 2005 · 109 citations · Full text

Histone Modifications, Hdac Inhibitors, Histone Hyperacetylation +17

Highly Potent and Selective Histone Deacetylase 6 Inhibitors Designed Based on a Small-Molecular Substrate

Takayoshi Suzuki, Akiyasu Kouketsu, Yukihiro Itoh et al. · Journal of Medicinal Chemistry · 2006 · 104 citations · Full text

Design, Synthesis, Structure−Selectivity Relationship, and Effect on Human Cancer Cells of a Novel Series of Histone Deacetylase 6-Selective Inhibitors

Yukihiro Itoh, Takayoshi Suzuki, Akiyasu Kouketsu et al. · Journal of Medicinal Chemistry · 2007 · 102 citations · Full text

Thiol-based SAHA analogues as potent histone deacetylase inhibitors

Takayoshi Suzuki, Akiyasu Kouketsu, Azusa Matsuura et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 92 citations · Full text

Medicinal Chemistry, Medicine, Pharmacotherapy +5

Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design

Takayoshi Suzuki, Azusa Matsuura, Akiyasu Kouketsu et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 61 citations · Full text

Mechanism-based Drug Design, Medicinal Chemistry, Biochemistry +10