The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Stephen B. Willingham, Jens-Peter Volkmer, Andrew J. Gentles, +41

Proceedings of the National Academy of Sciences

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

Mark P. Chao, Siddhartha Jaiswal, Rachel Weissman-Tsukamoto, +9

Science Translational Medicine

Anti-CD47 antibody–mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

Diane Tseng, Jens-Peter Volkmer, Stephen B. Willingham, +8

Proceedings of the National Academy of Sciences

Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy

Amira Barkal, Kipp Weiskopf, Kevin S. Kao, +15

Nature Immunology

Cancer ImmunosurveillanceMhc ClassImmunologyImmunologic MechanismAntigen Processing +6

Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies

Kipp Weiskopf, Aaron M. Ring, Chia Chi M. Ho, +8

Science

Cancer ImmunosurveillanceCd47 AntagonistImmunoengineeringImmunologyTumor Immunity +12

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

Kipp Weiskopf, Nadine S. Jahchan, Peter J. Schnorr, +31

Journal of Clinical Investigation

Immune EvasionCd47-blocking ImmunotherapiesCancer ImmunosurveillanceMedicineImmune Regulation +12

Asterless is a scaffold for the onset of centriole assembly

Nikola S. Dzhindzhev, Quan D. Yu, Kipp Weiskopf, +7

Nature

BiologyPattern FormationCell DivisionNatural SciencesSelf-assembly +4

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity

Nan Ring, Dietmar Herndler‐Brandstetter, Kipp Weiskopf, +11

Proceedings of the National Academy of Sciences

Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma

Badreddin Edris, Kipp Weiskopf, Anne Kathrin Volkmer, +10

Proceedings of the National Academy of Sciences

Tumor-associated MacrophagesImmunologyResident MacrophagesPathologyImmunoediting +22

Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer

Holbrook E. Kohrt, Roch Houot, Kipp Weiskopf, +11

Journal of Clinical Investigation