John C. Joly

The SecA and SecY subunits of translocase are the nearest neighbors of a translocating preprotein, shielding it from phospholipids.

John C. Joly, William Wickner · The EMBO Journal · 1993 · 174 citations · Full text

Protein Secretion, Protein Function, Biochemistry +8

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases

Meixia Zhou, Yongping Crawford, Domingos Ng et al. · Journal of Biotechnology · 2011 · 147 citations

Animal Physiology, Pyruvate Dehydrogenase Kinases, Oocyte +8

Translocation can drive the unfolding of a preprotein domain.

Robert A. Arkowitz, John C. Joly, William Wickner · The EMBO Journal · 1993 · 127 citations · Full text

Protein Function, Protein Folding, Molecular Biology +4

Tethering of CpxP to the inner membrane prevents spheroplast induction of the Cpx envelope stress response

Tracy Raivio, Michael W. Laird, John C. Joly et al. · Molecular Microbiology · 2000 · 109 citations

Overexpression of <i>Escherichia coli</i> oxidoreductases increases recombinant insulin-like growth factor-I accumulation

John C. Joly, Wilson Leung, James R. Swartz · Proceedings of the National Academy of Sciences · 1998 · 101 citations

Protein Secretion, Engineering, Molecular Biology +24