V. Somayaji

Relationship between amidic distortion and ease of hydrolysis in base. If amidic resonance does not exist, then what accounts for the accelerated hydrolysis of distorted amides?

Andrew J. Bennet, Qing Ping Wang, H. Slebocka‐Tilk et al. · Journal of the American Chemical Society · 1990 · 106 citations

Engineering, Biochemistry, Natural Sciences +6

Distorted amides as models for activated peptide N-C:O units produced during enzyme-catalyzed acyl transfer reactions. 1. The mechanism of hydrolysis of 3,4-dihydro-2-oxo-1,4-ethanoquinoline and 2,3,4,5-tetrahydro-2-oxo-1,5-ethanobenzazepine

V. Somayaji, R. S. Brown · The Journal of Organic Chemistry · 1986 · 95 citations

Biochemistry, Medicine, Enzyme Catalysis +10

The influence of altered amidic resonance on the infrared and carbon-13 and nitrogen-15 NMR spectroscopic characteristics and barriers to rotation about the N-C(O) bond in some anilides and toluamides

Andrew J. Bennet, V. Somayaji, Richard S. Brown et al. · Journal of the American Chemical Society · 1991 · 92 citations

Molecular Sciences, Biochemistry, Natural Sciences +12

Direct O-acylation of small molecules containing CO2----HN .rarw. HO units by a distorted amide: enhancement of amine basicity by a pendant carboxylate in a serine protease mimic

Kathryn Skorey, V. Somayaji, R. S. Brown · Journal of the American Chemical Society · 1989 · 30 citations

Ho Units, Engineering, Biochemistry +14

Molecular structure of 3,4,5-trihydro-2-oxo-1,5-ethanobenzazepine and its reaction with .beta.-amino alcohols as a model for the acylation step of the serine proteases

V. Somayaji, Kathryn Skorey, R. S. Brown et al. · The Journal of Organic Chemistry · 1986 · 24 citations

Molecular Pharmacology, .Beta.-amino Alcohols, Bioorganic Chemistry +15