Tetsunari Kihira

Antitumor activity of tumor necrosis factor-alpha conjugated with polyvinylpyrrolidone on solid tumors in mice.

Haruhiko Kamada, Yasuo Tsutsumi, Yoko Yamamoto et al. · PubMed · 2000 · 93 citations

Antitumor Activity, Solid Tumors, Novel Polymer Conjugation +16

Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency

Yasuo Tsutsumi, Tetsunari Kihira, Shin‐ichi Tsunoda et al. · British Journal of Cancer · 1995 · 64 citations · Full text

Tumor Biology, Engineering, Polymer-drug Conjugate +11

Molecular design of hybrid tumor necrosis factor-alpha III: polyethylene glycol-modified tumor necrosis factor-alpha has markedly enhanced antitumor potency due to longer plasma half-life and higher tumor accumulation.

Yasuo Tsutsumi, Tetsunari Kihira, Shin‐ichi Tsunoda et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 40 citations

PEGylation of lnterleukin-6 Effectively Increases Its Thrombopoietic Potency

Yasuo E Tsutsumi, Shin-ichi S Tsunoda, Haruhiko Kamada et al. · Thrombosis and Haemostasis · 1997 · 37 citations

Immunology, Immunotherapy, Inflammation +17

Chemical Modification of Natural Human Tumor Necrosis Factor‐α with Polyethylene Glycol Increases Its Anti‐tumor Potency

Yasuo Tsutsumi, Tetsunari Kihira, Susumu Yamamoto et al. · Japanese Journal of Cancer Research · 1994 · 37 citations · Full text

Chemoprevention Strategy, Immunology, Chemical Modification +16