CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

Ron Firestein, Adam J. Bass, So Young Kim, +25

Nature

Tumor BiologyOncologyOncogenic AgentMedicineColorectal Cancer +8

Binding of 14-3-3 Proteins to the Protein Kinase Raf and Effects on Its Activation

Ellen Freed, Marc Symons, Susan G. Macdonald, +2

Science

14-3-3 ZetaProtein FunctionSignal TransductionSignaling PathwayCell Regulation +11

Emi1 Is a Mitotic Regulator that Interacts with Cdc20 and Inhibits the Anaphase Promoting Complex

Julie D.R. Reimann, Ellen Freed, Jerry Y. Hsu, +3

Cell

Mitotic RegulatorAnaphase Promoting ComplexSignal TransductionSignaling PathwayCell Division +10

Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer

John Souglakos, Juliet Philips, R Wang, +15

British Journal of Cancer

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

Ellen Freed, Kathleen R. Lacey, Philip Huie, +4

Genes & Development

Relationship of CDX2 Loss with Molecular Features and Prognosis in Colorectal Cancer

Yoshifumi Baba, Katsuhiko Nosho, Kaori Shima, +8

Clinical Cancer Research

A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.

Ellen Freed, James Gailit, Peter van der Geer, +2

The EMBO Journal

Signal TransductionProtein Kinase CMedicineReceptor Tyrosine KinasePathology +6

High‐resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss

Matthew H. Kulke, Ellen Freed, Derek Y. Chiang, +4

Genes Chromosomes and Cancer

TCF4 and CDX2, major transcription factors for intestinal function, converge on the same <i>cis</i> -regulatory regions

Michael P. Verzi, Pantelis Hatzis, Rita Sulahian, +10

Proceedings of the National Academy of Sciences

Discovery of (+)-<i>N</i>-(3-Aminopropyl)-<i>N</i>-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-<i>d</i>]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent

Maria‐Elena Theoclitou, Brian Aquila, M. Block, +22

Journal of Medicinal Chemistry