Tanja Zeugin

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

Masaaki Kagimoto, Markus H. Heim, Keiko Kagimoto et al. · Journal of Biological Chemistry · 1990 · 267 citations · Full text

Medicine, Genetics, Pharmacology +17

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

Kim Brøsen, Tanja Zeugin, Urs Meyer · Clinical Pharmacology & Therapeutics · 1991 · 114 citations

Medicine, Biochemistry, Pharmacology +16

Sequence requirements for cytochrome P-450IID1 catalytic activity. A single amino acid change (Ile380 Phe) specifically decreases Vmax of the enzyme for bufuralol but not debrisoquine hydroxylation.

Eiji Matsunaga, Tanja Zeugin, Ulrich M. Zanger et al. · Journal of Biological Chemistry · 1990 · 63 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

In-vivo and in-vitro dextromethorphan metabolism in SD and DA rat

Thomas Zysset, Tanja Zeugin, A Küpfer · Biochemical Pharmacology · 1988 · 44 citations

Medicine, Pharmacokinetics, Pharmacology +6

Therapeutic Monitoring of Albendazole

Tanja Zeugin, Thomas Zysset, Jacques Cotting · Therapeutic Drug Monitoring · 1990 · 35 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +17