Nichole O’Connell

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

William McCoull, Tony Cheung, Erica Anderson et al. · ACS Chemical Biology · 2018 · 133 citations · Full text

Hematological Malignancy, Lymphoid Neoplasia, B-cell Lymphoma 6 +14

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

Bernard Barlaam, Robert Casella, Justin Cidado et al. · Journal of Medicinal Chemistry · 2020 · 98 citations · Full text

Discovery of Pyrazolo[1,5-<i>a</i>]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

William McCoull, Roman Abrams, Erica Anderson et al. · Journal of Medicinal Chemistry · 2017 · 78 citations · Full text

The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme

Nichole O’Connell, Scott R. Nichols, Ewald Heroes et al. · Structure · 2012 · 75 citations · Full text

Protein Function, Biochemistry, Reactive Nitrogen Specie +7

Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling <i>in Vivo</i>

James J. Dowling, Marat Alimzhanov, Larry Bao et al. · ACS Medicinal Chemistry Letters · 2016 · 54 citations · Full text

Molecular Pharmacology, Ck2 Kinase Activity, Signal Transduction +14