Karen M. Stoffan

Discovery of a 1<i>H</i>-Benzoimidazol-2-yl)-1<i>H</i>-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

Mark D. Wittman, Joan M. Carboni, Ricardo M. Attar et al. · Journal of Medicinal Chemistry · 2005 · 135 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)

Upender Velaparthi, Mark D. Wittman, Peiying Liu et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of a Fluoroindolo[2,3-<i>a</i>]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11

Mark G. Saulnier, Balu Balasubramanian, Byron H. Long et al. · Journal of Medicinal Chemistry · 2005 · 36 citations · Full text

Medicine, Oncology, Pharmacology +8

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- <scp>d</scp>-glucopyranosyl]-5<i>H</i>,13<i>H</i>-benzo[<i>b</i>]- thienyl[2,3-<i>a</i>]pyrrolo[3,4-<i>c</i>]carbazole- 5,7(6<i>H</i>)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model

Balu Balasubramanian, Denis R. St. Laurent, Mark G. Saulnier et al. · Journal of Medicinal Chemistry · 2004 · 36 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase

Mark D. Wittman, Balu Balasubramanian, Karen M. Stoffan et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 28 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8