John P. Shilvock

Intermediates for incorporation of tetrahydroxypipecolic acid analogues of α- and β-d-mannopyranose into combinatorial libraries: unexpected nanomolar-range hexosaminidase inhibitors. Synthesis of α- and β-homomannojirimycin

John P. Shilvock, Robert J. Nash, Janet D. Lloyd et al. · Tetrahedron Asymmetry · 1998 · 33 citations

Pharmacy, Medicinal Chemistry, Combinatorial Chemistry +11

Inhibition of naringinase (L-rhamnosidase) by piperidine analogues of L-rhamnose: Scaffolds for libraries incorporating trihydroxypipecolic acids

John P. Shilvock, Joseph R. Wheatley, Benjamin G. Davis et al. · Tetrahedron Letters · 1996 · 33 citations

Pharmacy, Biochemistry, Medicinal Chemistry +14

Synthesis of homorhamnojirimycins and related trihydroxypipecolic acid derivatives via divergent bicyclic amino lactone intermediates: Inhibition of naringinase (L-rhamnosidase) and dTDP-rhamnose biosynthesis

John P. Shilvock, Joseph R. Wheatley, Robert J. Nash et al. · Journal of the Chemical Society Perkin Transactions 1 · 1999 · 31 citations

Pharmacy, Medicinal Chemistry, Enzymology +11

The Synthesis of Deoxygalactostatin and 2,6-Imino-heptitol Derivatives via Stannane Mediated Hydroxymethylation of 5-Azido-1,4-lactones

John P. Shilvock, George W. J. Fleet · Synlett · 1998 · 24 citations

Pharmacy, Biochemistry, Medicinal Chemistry +8

Piperidine analogues of D-galactose as potent inhibitors of α-galactosidase: Synthesis by stannane-mediated hydroxymethylation of 5-azido-1,4-lactones. Structural relationships between D-galactosidase and L-rhamnosidase inhibitors

John P. Shilvock, Robert J. Nash, Alison A. Watson et al. · Journal of the Chemical Society Perkin Transactions 1 · 1999 · 22 citations

Pharmacy, Medicinal Chemistry, Carbohydrate Chemistry +12