The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Jeff Sevigny, Ping Chiao, Thierry Bussière, +25

Nature

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineImmunologyDegenerative Pathology +5

First‐in‐human, double‐blind, placebo‐controlled, single‐dose escalation study of aducanumab (BIIB037) in mild‐to‐moderate Alzheimer's disease

J L Ferrero, Leslie Williams, Heather Stella, +4

Alzheimer s & Dementia Translational Research & Clinical Interventions

Thrombospondin-1 Mimetic Peptide Inhibitors of Angiogenesis and Tumor Growth:  Design, Synthesis, and Optimization of Pharmacokinetics and Biological Activities

Fortuna Haviv, Michael F. Bradley, Douglas Kalvin, +18

Journal of Medicinal Chemistry

Peptide 1ImmunologyBiological ActivitiesPharmacotherapyHuaec Cells +17

Metabolism and disposition of clarithromycin in man.

J L Ferrero, Barbara A. Bopp, Kennan C. Marsh, +7

Drug Metabolism and Disposition

In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices.

A. David Rodrigues, Darcy J. Mulford, R D Lee, +6

Drug Metabolism and Disposition

Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193.

Joseph M. Machinist, Manuela Mayer, Manjunath S. Shet, +2

Drug Metabolism and Disposition

The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans.

A. David Rodrigues, J L Ferrero, Maria Amann, +7

Drug Metabolism and Disposition

Preclinical Pharmacokinetics of a HepDirect Prodrug of a Novel Phosphonate-Containing Thyroid Hormone Receptor Agonist

James M. Fujitaki, Edward E. Cable, Bruce R. Ito, +8

Drug Metabolism and Disposition

In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes). A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation.

A. David Rodrigues, Michael Kukulka, J L Ferrero, +1

Drug Metabolism and Disposition

Metabolism of caffeine by mouse liver microsomes: GSH or cytosol causes a shift in products from 1, 3, 7-trimethylurate to a substituted diaminouracil

J L Ferrero, Allen H. Neims

Life Sciences

Energy MetabolismBiochemistryMedicineLiver PhysiologyMetabolomic Profiling +6