MicroRNA-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting tumor suppressor candidate 3 in glioblastoma

Zhen-Xiu Cheng, Wenbo Yin, Zhongyu Wang

International Journal of Molecular Medicine

Chemoprevention StrategyImmunotherapeuticsHigh-grade GliomasCancer BiologyGlioma +19

Design, synthesis and biological evaluation of novel benzofuran derivatives as potent LSD1 inhibitors

Xiangyu Zhang, Hai‐Lan Huang, Ziheng Zhang, +8

European Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +9

Bidirectional effects of benzodiazepine binding site ligands in the passive avoidance task: differential antagonism by flumazenil and ?-CCt

Miroslav M. Savić, Dragan Obradović, Nenad D. Ugrešić, +3

Behavioural Brain Research

NeuropsychologyPsychoactive DrugBehavioral NeuroscienceAddictionMedicine +11

Ligand-based pharmacophore modeling, virtual screening and biological evaluation to identify novel TGR5 agonists

Shizhen Zhao, Xinping Li, Wenjing Peng, +7

RSC Advances

Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors

Jing Guo, Fan Zhao, Wenbo Yin, +8

European Journal of Medicinal Chemistry

Medicinal ChemistryStructure-activity Relationships StudyBiochemistryPak4 InhibitorsNatural Sciences +6

Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis

Wenbo Yin, Tianxiao Wu, Lei Liu, +11

Journal of Medicinal Chemistry

Discovery of the First Potent, Selective, and <i>In Vivo</i> Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of <i>TRIM37</i>-Amplified Breast Cancer

Yin Sun, Yanli Xue, Pengkun Sun, +14

Journal of Medicinal Chemistry

Discovery of quinazoline derivatives CZw-124 as a pan-TRK inhibitor with potent anticancer effects in vitro and in vivo

Tianxiao Wu, Qiaohua Qin, Ruicheng Lv, +8

European Journal of Medicinal Chemistry

Medicinal ChemistryOncologyQuinazoline Derivatives Czw-124Pan-trk InhibitorNovel Therapy +9

Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors

Tianxiao Wu, Chu Zhang, Ruicheng Lv, +9

European Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +6

Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study

Yin Sun, Ruifeng Wang, Yu Sun, +9

European Journal of Medicinal Chemistry

Drug TargetingMedicineBiological StudyBronchial NeoplasmTumor Targeting +9