Keith R. Mulholland

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

Scott P. France, Shahed Hussain, Andrew M. Hill et al. · ACS Catalysis · 2016 · 203 citations

Engineering, Biochemistry, Chemistry +17

A Survey of the Borrowing Hydrogen Approach to the Synthesis of some Pharmaceutically Relevant Intermediates

John Leonard, A. John Blacker, Stephen P. Marsden et al. · Organic Process Research & Development · 2015 · 166 citations

Natural Sciences, Chemistry, Medicinal Chemistry +11

An (<i>R</i>)‐Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines

Shahed Hussain, Friedemann Leipold, Henry Man et al. · ChemCatChem · 2015 · 151 citations · Full text

Life Sciences, Biochemistry, Biotechnology +17

Biocatalytic <i>N</i>-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

Jeremy I. Ramsden, Rachel S. Heath, Sasha R. Derrington et al. · Journal of the American Chemical Society · 2019 · 118 citations · Full text

Natural Sciences, Biotechnology, Chemistry +17

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2<i>H</i>-pyran-4-yl)-1,3-dihydro-2<i>H</i>-imidazo[4,5-<i>c</i>]quinolin-2-one)

Kurt G. Pike, Bernard Barlaam, Elaine Cadogan et al. · Journal of Medicinal Chemistry · 2018 · 116 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14