Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model

Bo Ram Beck, Bonggun Shin, Yoonjung Choi, +2

Computational and Structural Biotechnology Journal

Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation

Sung Ho Park, Kyuho Kang, Yu Qiao, +4

Nature Immunology

InflammationCytokineAutoimmune DiseaseImmune Cell DevelopmentImmunology +9

Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF

Kyuho Kang, Sung Ho Park, Janice Chen, +8

Immunity

InflammationCytokineTranscriptional RegulationTranscription Factor MafHuman Macrophages +7

AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2

Hana Kim, Keunsoo Kang, Joomyeong Kim

Nucleic Acids Research

Mammalian Aebp2Molecular RegulationGeneticsMolecular BiologyZinc Finger Protein +18

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness

Tackhoon Kim, Suk-Jin Yang, Daehee Hwang, +12

Nature Communications

Tumor BiologyLineage PlasticityBreast OncologyYap-induced Cancer StemnessMedicine +11

Predicting commercially available antiviral drugs that may act on the novel coronavirus (2019-nCoV), Wuhan, China through a drug-target interaction deep learning model

Bo Ram Beck, Bonggun Shin, Yoonjung Choi, +2

Viral Polymerase StructureAvailable Antiviral DrugsImmunologyAntiviral DrugMt-dti Model +15

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation

Kyuho Kang, Mahesh Bachu, Sung Ho Park, +4

Nature Communications

Barrier to autointegration factor 1, procollagen‐lysine, 2‐oxoglutarate 5‐dioxygenase 3, and splicing factor 3b subunit 4 as early‐stage cancer decision markers and drivers of hepatocellular carcinoma

Qingyu Shen, Jung Woo Eun, Kyoung Bun Lee, +15

Hepatology

Human Histone H3K79 Methyltransferase DOT1L Methyltransferase Binds Actively Transcribing RNA Polymerase II to Regulate Gene Expression

Seung-Kyoon Kim, Inkyung Jung, Hosuk Lee, +8

Journal of Biological Chemistry

The T47D cell line is an ideal experimental model to elucidate the progesterone-specific effects of a luminal A subtype of breast cancer

Sungryul Yu, Taemook Kim, Kyung Hyun Yoo, +1

Biochemical and Biophysical Research Communications

Breast OncologyMedicineGynecologyT47d Cell LineIdeal Experimental Model +6