Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

Robert Wirka, Dhananjay Wagh, David T. Paik, +18

Nature Medicine

Signal TransductionAtheroprotective RolesSignaling PathwaySkeletal MuscleMedicine +7

Metabolic network failures in Alzheimer's disease: A biochemical road map

Jon B. Toledo, Matthias Arnold, Gabi Kastenmüller, +40

Alzheimer s & Dementia

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity

Ivan Carcamo‐Orive, Gabriel E. Hoffman, Paige Cundiff, +20

Cell stem cell

Genetic AnalysisAllelic VariantPhenotypic VariationFunctional GenomicsVariant Interpretation +10

Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro

Mika P. Cadiz, Tanner Jensen, Jonathon Sens, +6

Molecular Neurodegeneration

Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy

Mariet Allen, Xue Wang, Daniel Serie, +22

Acta Neuropathologica

The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target

Vladislav Petyuk, Rui Chang, Manuel Ramirez‐Restrepo, +34

Brain

Neurochemical BiomarkersSocial SciencesS DiseaseAlzheimer's DiseaseHuman Brainome +18

Predictive metabolic networks reveal sex‐ and <i>APOE</i> genotype‐specific metabolic signatures and drivers for precision medicine in Alzheimer's disease

Rui Chang, Eugenia Trushina, Kuixi Zhu, +13

Alzheimer s & Dementia

EXPLORING THE REPRODUCIBILITY OF PROBABILISTIC CAUSAL MOLECULAR NETWORK MODELS

Ariella Cohain, Aparna A. Divaraniya, Kuixi Zhu, +6

Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness

Ivan Carcamo‐Orive, Marc Henrion, Kuixi Zhu, +11

PLoS Computational Biology

GeneticsGenetic EpidemiologyGene Regulatory NetworkGene Expression ProfilingInsulin Signaling +23

Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer’s disease

Julie P. Merchant, Kuixi Zhu, Marc Henrion, +9

Communications Biology