Potentiation of a Topoisomerase I Inhibitor, Karenitecin, by the Histone Deacetylase Inhibitor Valproic Acid in Melanoma: Translational and Phase I/II Clinical Trial

Adil Daud, Jana L. Dawson, Ronald C. DeConti, +8

Clinical Cancer Research

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma

Joel G. Turner, Trinayan Kashyap, Jana L. Dawson, +8

Oncotarget

Hematological MalignancyTumor BiologyProteasome Inhibitor ResistanceMedicineImmunology +11

Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors

Joel G. Turner, Jana L. Dawson, Steven Grant, +8

Journal of Hematology & Oncology

Human Multiple Myeloma Cells Are Sensitized to Topoisomerase II Inhibitors by CRM1 Inhibition

Joel G. Turner, Douglas C. Marchion, Jana L. Dawson, +4

Cancer Research

CRM1 Inhibition Sensitizes Drug Resistant Human Myeloma Cells to Topoisomerase II and Proteasome Inhibitors both In Vitro and Ex Vivo

Joel G. Turner, Jana L. Dawson, Michael F. Emmons, +5

Journal of Cancer

Hematological MalignancyTumor BiologyEx VivoProteasome InhibitorsNuclear Export +13

Phase I Trial of Bortezomib (PS-341; NSC 681239) and Alvocidib (Flavopiridol; NSC 649890) in Patients with Recurrent or Refractory B-Cell Neoplasms

Beata Holkova, Edward Brent Perkins, Viswanathan Ramakrishnan, +17

Clinical Cancer Research

Phase I Clinical Trial of Selinexor in Combination with Daunorubicin and Cytarabine in Previously Untreated Poor-Risk Acute Myeloid Leukemia

Kendra Sweet, Rami S. Komrokji, Eric Padron, +10

Clinical Cancer Research

Phase I Trial of Bortezomib (PS-341; NSC 681239) and “Nonhybrid” (Bolus) Infusion Schedule of Alvocidib (Flavopiridol; NSC 649890) in Patients with Recurrent or Refractory Indolent B-cell Neoplasms

Beata Holkova, Maciej Kmieciak, Edward Brent Perkins, +23

Clinical Cancer Research

Melphalan and Exportin 1 Inhibitors Exert Synergistic Antitumor Effects in Preclinical Models of Human Multiple Myeloma

Joel G. Turner, Yan Cui, Alexis A. Bauer, +7

Cancer Research

ImmunologyExportin 1Tumor BiologyHematological MalignancyMetronomic Therapy +16

Hepatic Biliary and Pancreatic Surgery

Jana L. Dawson

Gut

HepatologyBiliary TractLiver PhysiologyGastroenterologyPancreatic Surgery +4