Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells

Wim Pierson, Bénédicte Cauwe, Antonia N. Policheni, +17

Nature Immunology

T-regulatory CellImmunologyNiche-filling CapacityCell DeathImmunologic Mechanism +6

The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release

Oliver Brain, Benjamin M. J. Owens, Tica Pichulik, +17

Immunity

InflammationIntracellular Sensor Nod2Il-23 ReleaseCytokineAutoimmune Disease +9

The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity

James Dooley, Josselyn E. Garcia‐Perez, Jayasree Sreenivasan, +13

Diabetes

Balance Between HomeostaticUnfolded Protein StressPathological Glucose HandlingGlucose RegulationInsulin Signaling +19

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

James Dooley, Lei Tian, Susann Schönefeldt, +26

Nature Genetics

Metabolic SyndromeGenetic DeterminantGeneticsDiabetesGenetic Epidemiology +5

IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis

Stéphanie Humblet‐Baron, Dean Franckaert, James Dooley, +8

Journal of Allergy and Clinical Immunology

InflammationAutoimmune DiseaseCd8 T CellsT-regulatory CellHematology +10

Rapamycin increases survival in ALS mice lacking mature lymphocytes

Kim A. Staats, Sara Hernández, Susann Schönefeldt, +6

Molecular Neurodegeneration

Type 1 Diabetes in NOD Mice Unaffected by Mast Cell Deficiency

Dario A. Gutierrez, Wenxian Fu, Susann Schönefeldt, +6

Diabetes

Mast Cell DisorderImmunologyImmune RegulationImmunotherapyImmune Dysregulation +14

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis

Kim A. Staats, Susann Schönefeldt, M. Van Rillaer, +5

Frontiers in Cellular Neuroscience

Neurochemical BiomarkersSynaptic SignalingSocial SciencesNeuroregenerationNeurobiology Of Disease +19

Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice

Lei Tian, Gert De Hertogh, Maya Fedeli, +7

Journal of Autoimmunity

InflammationAutoimmune DiseaseAutoimmune PathologyT-regulatory CellImmunology +10

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia

Tobias Suske, Helena Sorger, Gabriele Manhart, +41

Journal of Clinical Investigation