Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking

Richard S. Mitchell, Chris Katsura, Mark Skasko, +7

PLoS Pathogens

Direct Restriction of Virus Release and Incorporation of the Interferon-Induced Protein BST-2 into HIV-1 Particles

Kathleen Fitzpatrick, Mark Skasko, Thomas J. Deerinck, +3

PLoS Pathogens

Viral ReplicationHiv-1 VpuImmunologyMolecular BiologyVirus Release +14

Role of retroviral restriction factors in the interferon-α–mediated suppression of HIV-1 in vivo

Satish K. Pillai, Mohamed Abdel‐Mohsen, John Guatelli, +15

Proceedings of the National Academy of Sciences

HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions

Mark Skasko, Yan Wang, Ye Tian, +6

Journal of Biological Chemistry

Proteinlipid InteractionImmunologyMolecular BiologyInnate ImmunityAnalytical Ultracentrifugation +19

BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: Evidence for a post-ER mechanism of Vpu-action

Mark Skasko, Andrey Tokarev, Cheng‐Chang Chen, +3

Virology

Post-er MechanismSignal TransductionViral PersistenceHuman RetrovirusImmunology +9

Mechanistic Differences in RNA-dependent DNA Polymerization and Fidelity between Murine Leukemia Virus and HIV-1 Reverse Transcriptases

Mark Skasko, Kellie K. Weiss, Holly M. Reynolds, +3

Journal of Biological Chemistry

Murine Leukemia VirusViral ReplicationMechanistic DifferencesEngineeringHiv-1 Reverse Transcriptases +13

A Role for dNTP Binding of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Viral Mutagenesis

Kellie K. Weiss, Renxiang Chen, Mark Skasko, +5

Biochemistry

Reduced dNTP Binding Affinity of 3TC-resistant M184I HIV-1 Reverse Transcriptase Variants Responsible for Viral Infection Failure in Macrophage

Varuni K. Jamburuthugoda, Jose M. Santos-Velazquez, Mark Skasko, +7

Journal of Biological Chemistry

Viral ReplicationDntp Binding AffinityNatural SciencesHuman RetrovirusPathogenesis +13

Compensatory Role of Human Immunodeficiency Virus Central Polypurine Tract Sequence in Kinetically Disrupted Reverse Transcription

Mark Skasko, Baek Kim

Journal of Virology

Viral ReplicationCompensatory RoleNatural SciencesHuman RetrovirusImmunology +12