Somatic mutation landscapes at single-molecule resolution

Federico Abascal, Luke M. R. Harvey, Emily Mitchell, +29

Nature

Somatic VariantNatural SciencesDirected EvolutionComputational BiologyDna Replication +2

Clonal dynamics of haematopoiesis across the human lifespan

Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, +26

Nature

The longitudinal dynamics and natural history of clonal haematopoiesis

Margarete A. Fabre, José Guilherme de Almeida, Edoardo Fiorillo, +18

Nature

Life histories of myeloproliferative neoplasms inferred from phylogenies.

Nicholas Williams, Joe Lee, Emily Mitchell, +9

Apollo (University of Cambridge)

Increased somatic mutation burdens in normal human cells due to defective DNA polymerases

Philip S. Robinson, Tim Coorens, Claire Palles, +17

Nature Genetics

Lineage tracing of human development through somatic mutations

Michael Spencer Chapman, Anna Maria Ranzoni, Brynelle Myers, +13

Nature

Developmental BiologySomatic VariantGeneticsMorphogenesisLineage Tracing +1

Diverse mutational landscapes in human lymphocytes

Heather E. Machado, Emily Mitchell, Nina Friesgaard Øbro, +22

Nature

Clonal dynamics of haematopoiesis across the human lifespan

Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, +26

Blood ProductionGeneticsImmunologyBlood CellStem Cell Biology +15

Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis

Nicholas Bernstein, Michael Spencer Chapman, Kudzai Nyamondo, +6

Nature Genetics

Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans

Nicole Mende, Hugo Bastos, Antonella Santoro, +21

Blood

Extramedullary Hematopoietic StemAdult Stem CellImmunologyBlood CellBone Marrow Failure +20