Non-peptide δ opioid agonists and antagonists

Giulio Dondio, Silvano Ronzoni, Paola Petrillo

Expert Opinion on Therapeutic Patents

Peptide SciencePharmacotherapyExperimental PharmacologyPharmacodynamic ModelingMolecular Pharmacology +18

Protective effect of alpha7 nAChR: Behavioural and morphological features on neuropathy

Alessandra Pacini, Lorenzo Di Cesare Mannelli, Laura Bonaccini, +3

Pain

Discovery of a Novel Class of Substituted Pyrrolooctahydroisoquinolines as Potent and Selective δ Opioid Agonists, Based on an Extension of the Message−Address Concept

Giulio Dondio, Silvano Ronzoni, Drake S. Eggleston, +7

Journal of Medicinal Chemistry

Non-peptide δ opioid agonists and antagonists (Part II)

Giulio Dondio, Silvano Ronzoni, Paola Petrillo

Expert Opinion on Therapeutic Patents

Pain MedicinePeptide SciencePharmacotherapyExperimental PharmacologyPharmacodynamic Modeling +19

A New Synthetic Approach to 1-[(3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-benzimidazol-2-one (J-113397), the first non-peptide ORL-1 receptor antagonist

Carmela De Risi, G. P. POLLINI, Claudio Trapella, +3

Bioorganic & Medicinal Chemistry

BiochemistryMedicineNew Synthetic ApproachPharmacological AgentPeptide Synthesis +5

Lead generation and lead optimisation approaches in the discovery of selective, non-peptide ORL-1 receptor agonists and antagonists

Silvano Ronzoni, Ilaria Peretto, Giuseppe Giardina

Expert Opinion on Therapeutic Patents

Pain MedicineMolecular PainOpioid ReceptorLead IdentificationPharmacotherapy +18

Selective δ opioid receptor agonists for inflammatory and neuropathic pain

Giulio Dondio, Silvano Ronzoni, Carlo Farina, +4

Il Farmaco

Molecular PharmacologyPain TherapyPain DisordersHealth SciencesAcute Pain +12

Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain

Carlo Farina, Stefania Gagliardi, Carla Ghelardini, +5

Bioorganic & Medicinal Chemistry

Medicinal ChemistryHealth SciencesMedicinePain MedicineNeuropathic Pain +10

THE ROLE OF THE “SPACER" IN THE OCTAHYDROISOQUINOLINE SERIES: DISCOVERY OF SB 213698, A NON-PEPTIDIC, POTENT AND SELECTIVE <i>DELTA</i> OPIOID AGONIST

Giulio Dondio, Geoffrey D. Clarke, Giuseppe Giardina, +5

Analgesia

Molecular PharmacologyThe Octahydroisoquinoline SeriesBiochemistryMedicineNatural Sciences +8

Identification of small molecule agonists of the motilin receptor

Tom D. Heightman, Elizabeth A. Conway, David F. Corbett, +16

Bioorganic & Medicinal Chemistry Letters

BiochemistryG Protein-coupled ReceptorMedicineNatural SciencesMechanism Of Action +5