Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Maria José Diógenes, Raquel B. Dias, Diogo M. Rombo, +14

Journal of Neuroscience

Brain NeuronsSynaptic TransmissionNeurotransmitterMolecular BiologyNeurotransmission +20

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

Diana F. Lázaro, Eva Rodrigues, Ramona Langohr, +13

PLoS Genetics

Oligomeric SpeciesMolecular BiologySystematic ComparisonAutophagyDegenerative Pathology +15

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, +22

PLoS Biology

MitophagySirtuin GenesImmunologyCell DeathMolecular Biology +16

The NAD‐dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

Teresa F. Pais, Éva M. Szegő, Oldriska Marques, +6

The EMBO Journal

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

Guowei Yin, Tomás Lopes da Fonseca, Sibylle E. Eisbach, +15

Neurobiology of Disease

Neurodegenerative DiseasesSignal TransductionMolecular NeuroscienceBiochemistryNatural Sciences +12

The small GTPase Rab11 co-localizes with  -synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity

Oldriska Chutna, S. Gonçalves, Anna Villar‐Piqué, +11

Human Molecular Genetics

AutophagyDegenerative PathologyProtein MisfoldingSecretory PathwayCell Signaling +15

LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models

Patrícia Guerreiro, Yue Huang, Amanda M. Gysbers, +4

Journal of Molecular Medicine

LRRK2 Promotes Tau Accumulation, Aggregation and Release

Patrícia Guerreiro, Ellen Gerhardt, Tomás Lopes da Fonseca, +3

Molecular Neurobiology

Signal TransductionSignaling PathwayNatural SciencesAutophagyMolecular Biology +4

Reverse engineering synthetic antiviral amyloids

Emiel Michiels, Kenny Roose, Rodrigo Gallardo, +20

Nature Communications

Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure

Katerina Konstantoulea, Patrícia Guerreiro, Meine Ramakers, +11

The EMBO Journal

Protein AssemblyProtein FoldingNatural SciencesMolecular BiologyAmyloid Structure +4