Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry

Luca Fornelli, Daniel Ayoub, Konstantin Aizikov, +2

Analytical Chemistry

Top-down characterization of endogenous protein complexes with native proteomics

Owen S. Skinner, Nicole A. Haverland, Luca Fornelli, +8

Nature Chemical Biology

Proteomic TechnologyNatural SciencesNative ProteomicsProteasomeMolecular Biology +1

Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS

Luca Fornelli, Eugen Damoc, Paul M. Thomas, +5

Molecular & Cellular Proteomics

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

Luca Fornelli, Kristina Srzentić, Romain Huguet, +7

Analytical Chemistry

Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry

Yury O. Tsybin, Luca Fornelli, Carsten Stoermer, +5

Analytical Chemistry

The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells

Rafael D. Melani, Vincent R. Gerbasi, Lissa C. Anderson, +23

Science

EngineeringImmunologyBlood CellPathologyReference Map +18

Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

Kristina Srzentić, Luca Fornelli, Yury O. Tsybin, +57

Journal of the American Society for Mass Spectrometry

Middle-down Mass SpectrometryTd MsImmunologyBiological Mass SpectrometryImmunotherapy +21

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk

Ioanna Ntai, Luca Fornelli, Caroline J. DeHart, +9

Proceedings of the National Academy of Sciences

Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa

Kenneth R. Durbin, Luca Fornelli, Ryan T. Fellers, +3

Journal of Proteome Research

EngineeringPathologyMolecular BiologyComplex SystemsProteomic Technology +19

Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms

Romain Huguet, Christopher Mullen, Kristina Srzentić, +6

Analytical Chemistry