Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Fimasartan Following Single and Repeated Oral Administration in the Fasted and Fed States in Healthy Subjects

Yong Ha, Howard Lee, Soo Heui Paik, +5

American Journal of Cardiovascular Drugs

Fimasartan Following SingleHealthy SubjectsFed StatesMedicineClinical Pharmacology +2

Glucuronidation of fimasartan, a new angiotensin receptor antagonist, is mainly mediated by UGT1A3

Eun‐Sook Jeong, Yang Weon Kim, Hyo-Ji Kim, +6

Xenobiotica

Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats

Tae Hwan Kim, Soyoung Shin, Mohammad Bashir, +10

Xenobiotica

Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans

Tae Hwan Kim, Soyoung Shin, Cornelia B. Landersdorfer, +7

The AAPS Journal

Animal PhysiologyPharmacokinetic ModelingPharmacological StudyMedicinePhysiology +6

Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC–MS/MS with polarity switching: Application to ADME studies

Tae Hwan Kim, Min Gi Kim, Min Kim, +5

Talanta

Rat Biological MatricesBiochemistryMedicineBioanalysisMetabolomic Profiling +9

Absolute bioavailability and pharmacokinetics of the angiotensin II receptor antagonist fimasartan in healthy subjects

Jong‐Lyul Ghim, Soo Heui Paik, M. Hasanuzzaman, +4

The Journal of Clinical Pharmacology

HypertensionHealthy SubjectsCardiovascular PharmacologyPharmacotherapyIv Administration +17

Simultaneous determination of fimasartan, a novel antihypertensive agent, and its active metabolite in rat plasma by liquid chromatography–tandem mass spectrometry

Beom Soo Shin, Tae‐Hwan Kim, Soo Heui Paik, +6

Biomedical Chromatography

HypertensionPharmaceutical ScienceCardiovascular PharmacologyPharmacotherapyMultiple Reaction Monitoring +18

Fimasartan, Anti-hypertension Drug, Suppressed Inducible Nitric Oxide Synthase Expressions <i>via</i> Nuclear Factor-Kappa B and Activator Protein-1 Inactivation

Suran Ryu, Ji‐Sun Shin, Young‐Wuk Cho, +7

Biological and Pharmaceutical Bulletin

HypertensionInflammatory Lung DiseaseActivator Protein-1 InactivationLung InflammationNitric Oxide +26

Pharmacological Characterization of BR-A-657, a Highly Potent Nonpeptide Angiotensin II Receptor Antagonist

Yong Ha, Joo Han Lee, Je Hak Kim, +6

Biological and Pharmaceutical Bulletin

BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endothelial cells

Hye‐Eun Choi, Min‐Sang Yoo, Jung‐Hye Choi, +10

Bioorganic & Medicinal Chemistry Letters

AngiogenesisMedicineEndothelial DysfunctionVascular BiologyPharmacotherapy +4