A Novel Biased Allosteric Compound Inhibitor of Parturition Selectively Impedes the Prostaglandin F2α-mediated Rho/ROCK Signaling Pathway

Eugénie Goupil, Danaë Tassy, Carine B. Bourguet, +13

Journal of Biological Chemistry

Molecular RegulationChemical BiologyCellular PhysiologyMolecular PharmacologySignaling Pathway +21

Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context

Dominic Devost, Rory Sleno, Darlaine Pétrin, +6

Journal of Biological Chemistry

Molecular PhysiologySignal TransductionCellular ContextG Protein-coupled ReceptorFunctional Selectivity +9

Angiotensin II Type I and Prostaglandin F2α Receptors Cooperatively Modulate Signaling in Vascular Smooth Muscle Cells

Eugénie Goupil, Dany Fillion, Stéphanie Clément, +8

Journal of Biological Chemistry

Combining protein complementation assays with resonance energy transfer to detect multipartner protein complexes in living cells

R. Victor Rebois, Mélanie Robitaille, Darlaine Pétrin, +3

Methods

Living CellsProtein FunctionProtein AssemblyMolecular Biological MethodNatural Sciences +10

C5L2 and C5aR interaction in adipocytes and macrophages: Insights into adipoimmunology

Pegah Poursharifi, Marc Lapointe, Darlaine Pétrin, +4

Cellular Signalling

InflammationEnergy HomeostasisSignal TransductionPhysiologyImmunology +10

Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization

Paulina K. Wrzal, Dominic Devost, Darlaine Pétrin, +5

Cellular Signalling

Molecular PharmacologyMolecular PhysiologySignal TransductionG Protein-coupled ReceptorCell Signaling +9

The anti-apoptotic effect of leukotriene B4 in neutrophils: A role for phosphatidylinositol 3-kinase, extracellular signal-regulated kinase and Mcl-1

Darlaine Pétrin, Sylvie Turcotte, Annie-Kim Gilbert, +2

Cellular Signalling

InflammationCytokineAnti-inflammatoryAnti-apoptotic EffectLeukotriene B4 +10

Distinct Conformational Dynamics of Three G Protein-Coupled Receptors Measured Using FlAsH-BRET Biosensors

Kyla Bourque, Darlaine Pétrin, Rory Sleno, +3

Frontiers in Endocrinology

Novel, Gel-free Proteomics Approach Identifies RNF5 and JAMP as Modulators of GPCR Stability

Sébastien J. Roy, Irina Glazkova, Louis Fréchette, +8

Molecular Endocrinology

Protein AssemblyProteasome RecruitmentMolecular BiologySynaptic SignalingProteomic Technology +17

Designing BRET-based conformational biosensors for G protein-coupled receptors

Rory Sleno, Darlaine Pétrin, Dominic Devost, +3

Methods

Bret-based Conformational BiosensorsG Protein-coupled ReceptorPeptide LibraryConformational StudyBiophysics