Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

Marko Košiček, Martina Malnar, Alison Goate, +1

Biochemical and Biophysical Research Communications

Proteinlipid InteractionBiochemistryCholesterol AccumulationModel CellsNatural Sciences +6

Amyloid-β metabolism in Niemann-Pick C disease models and patients

Niklas Mattsson, Maria Olsson, Mikael K. Gustavsson, +13

Metabolic Brain Disease

BiochemistryDegenerative PathologyAmyloid-β MetabolismProtein MisfoldingNeurology

Niemann–Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway

Martina Malnar, Marko Košiček, Stefan Mitterreiter, +4

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Signal TransductionOxysterolBiochemistryMedicineNatural Sciences +9

Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation

John M. Ringman, Karen H. Gylys, Luis D. Medina, +15

Neuroscience Letters

Alzheimer's DiseaseNovel Psen1 MutationDementiaFrontotemporal DementiaNeurochemical Biomarkers +8

Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells

Martina Malnar, Marko Košiček, Ana Lisica, +6

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

OxysterolBace1 MisstraffickingLipoprotein MetabolismCellular BiochemistryMedicine +2

Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors

Tonko Dražić, Krešimir Molčanov, Vinay Sachdev, +7

European Journal of Medicinal Chemistry

Crystal StructurePharmaceutical SciencePharmacotherapyPharmaceutical ChemistryTranslational Pharmacology +14

Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors

Tonko Dražić, Vinay Sachdev, Christina Leopold, +6

Bioorganic & Medicinal Chemistry

BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains

Mirsada Čaušević, Kristina Dominko, Martina Malnar, +15

PLoS ONE

Inherited Lysosomal StorageSynaptic SignalingSocial SciencesAlzheimer's DiseaseNeurobiology Of Disease +16

Synthesis of new 2-aminoimidazolones with antiproliferative activity via base promoted amino-β-lactam rearrangement

Tonko Dražić, Katarina Vazdar, Mario Vazdar, +6

Tetrahedron

Antiproliferative ActivityNew 2-AminoimidazolonesSynthetic ChemistryPharmacologyPharmaceutical Chemistry +3

Cholesterol-Dependent Energy Transfer between Fluorescent Proteins—Insights into Protein Proximity of APP and BACE1 in Different Membranes in Niemann-Pick Type C Disease Cells

Bjoern von Einem, Petra Weber, Michael Wagner, +4

International Journal of Molecular Sciences