Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

Yao He, Liuhui Fu, Yiping Li, +10

Cell Metabolism

InflammationCancer ImmunosurveillanceDysbiosisMucosal ImmunologyAnticancer Therapy Efficacy +12

In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs

Lei Sun, Pan Li, Xiaohui Ju, +12

Cell

EngineeringRna Structure PredictionRna BiologyMolecular BiologyViral Structural Protein +2

Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2

Yinghui Liu, Gaowei Hu, Yuyan Wang, +22

Proceedings of the National Academy of Sciences

A novel cell culture system modeling the SARS-CoV-2 life cycle

Xiaohui Ju, Yunkai Zhu, Yuyan Wang, +10

PLoS Pathogens

Viral ReplicationEngineeringViral Polymerase MechanismMolecular BiologyReporter Gene +15

Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2

Shaojun Zhang, Wenze Huang, Lili Ren, +8

Cell Research

Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals a Broad Potential Host Range of SARS-CoV-2

Yinghui Liu, Gaowei Hu, Yuyan Wang, +14

Genetic AnalysisViral EvolutionEmerging Infectious DiseasesVirus EntryViral Pathogenesis +13

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

Wenlin Ren, Jun Lan, Xiaohui Ju, +12

PLoS Pathogens

Identification of functional cis-acting RNA elements in the hepatitis E virus genome required for viral replication

Xiaohui Ju, Guangtao Xiang, Mingli Gong, +7

PLoS Pathogens

Viral ReplicationHepatitis E VirusMolecular VirologyNatural SciencesGenetics +13

Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion

Wenlin Ren, Xiaohui Ju, Mingli Gong, +13

mBio

Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2

Wenlin Ren, Chong-Lei Fu, Yu Zhang, +8

Proceedings of the National Academy of Sciences