Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Anne Le, Charles R. Cooper, Arvin M. Gouw, +7

Proceedings of the National Academy of Sciences

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

Anne Le, Andrew N. Lane, Max Hamaker, +14

Cell Metabolism

Signal TransductionGlucose-independent Glutamine MetabolismBiochemistryCatabolismB Cells +9

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

Wei Liu, Anne Le, Chad N. Hancock, +4

Proceedings of the National Academy of Sciences

Proline OxidaseProline BiosynthesisMetabolic RemodelingCancer BiologyTumor Biology +20

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Yan Xiang, Zachary E. Stine, Jinsong Xia, +21

Journal of Clinical Investigation

Chemoprevention StrategyImmunologyGls InhibitorsCancer BiologyTumor Biology +14

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Liyang Cui, Arvin M. Gouw, Edward L. LaGory, +23

Nature Biotechnology

Tumor BiologyBreast OncologyMitochondrial FunctionMedicineMitochondrial Copper Depletion +4

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Alexander A. Shestov, Xiaojing Liu, Zheng Ser, +8

eLife

Limiting StepUpper GlycolysisGlycobiologyQuantitative DeterminantsMetabolic Remodeling +17

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Amira Elgogary, Qingguo Xu, Brad Poore, +20

Proceedings of the National Academy of Sciences

Glucose Metabolism in Cancer: The Warburg Effect and Beyond

Sminu Bose, Cissy Zhang, Anne Le

Advances in experimental medicine and biology

Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness

Yize Li, T. Mamie Lih, Saravana M. Dhanasekaran, +157

Cancer Cell

Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function

N.V. Rajeshkumar, Prasanta Dutta, Shinichi Yabuuchi, +10

Cancer Research

Chemoprevention StrategyPathologyMetabolic RemodelingWarburg EffectCancer Biology +16