In Vitro Antagonistic Properties of a New Angiotensin Type 1 Receptor Blocker, Azilsartan, in Receptor Binding and Function Studies

Mami Ojima, Hideki Igata, Masayuki Tanaka, +8

Journal of Pharmacology and Experimental Therapeutics

Na⁺/H⁺ exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats

Keiji Kusumoto, James V. Haist, Morris Karmazyn

American Journal of Physiology-Heart and Circulatory Physiology

Pharmacology of a non‐selective ET_A and ET_B receptor antagonist, TAK‐044 and the inhibition of myocardial infarct size in rats

Toshifumi Watanabe, Yumiko Awane, Shota Ikeda, +6

British Journal of Pharmacology

HypertensionNew EndothelinCardiovascular PharmacologyReceptor AntagonistPharmacotherapy +15

Positive Inotropic and Vasoconstrictive Effects of Endothelin-1 in in vivo and in vitro Experiments

Toshifumi Watanabe, Keiji Kusumoto, Takahito Kitayoshi, +1

Journal of Cardiovascular Pharmacology

Heart FailureVasoconstrictive EffectsCardiovascular FunctionPositive InotropicPublic Health +16

Effects of a new endothelin antagonist, TAK-044, on post-ischemic acute renal failure in rats

Keiji Kusumoto, Kazuki Kubo, Hitoshi Kandori, +5

Life Sciences

Renal FunctionMedicineKidney FailureChronic Kidney DiseasePhysiology +5

A new endothelin receptor antagonist, TAK-044, shows long-lasting inhibition of both ETA- and ETB-mediated blood pressure responses in rats.

Shota Ikeda, Yumiko Awane, Keiji Kusumoto, +2

Journal of Pharmacology and Experimental Therapeutics

Antihypertensive, insulin-sensitising and renoprotective effects of a novel, potent and long-acting angiotensin II type 1 receptor blocker, azilsartan medoxomil, in rat and dog models

Keiji Kusumoto, Hideki Igata, Mami Ojima, +8

European Journal of Pharmacology

HypertensionMedicineAntihypertensive TherapyPhysiologyDiabetes +7

Cyclic Hexapeptide Endothelin Receptor Antagonists Highly Potent for Both Receptor Subtypes ETA and ETB

Takashi Kikuchi, Tetsuya Ohtaki, Akira Kawata, +8

Biochemical and Biophysical Research Communications

Molecular PharmacologyFunctional SelectivityMedicinePhysiologyReceptor (Biochemistry) +6

Novel, Non-acylguanidine-type Na⁺/H⁺ Exchanger Inhibitors:  Synthesis and Pharmacology of 5-Tetrahydroquinolinylidene Aminoguanidine Derivatives

Shoji Fukumoto, Eiko Imamiya, Keiji Kusumoto, +3

Journal of Medicinal Chemistry

Role of Endogenous Endothelin in Extension of Rabbit Myocardial Infarction

Keiji Kusumoto, Yumiko Awane, Shuji Fujiwara, +1

Journal of Cardiovascular Pharmacology

ThrombosisHypertensionCardiovascular DiseaseAtherosclerosisRabbit Myocardial Infarction +12