Philip C. Biggin

Accurate calculation of the absolute free energy of binding for drug molecules

Matteo Aldeghi, Alexander Heifetz, Michael J. Bodkin et al. · Chemical Science · 2015 · 392 citations · Full text

A Hydrophobic Gating Mechanism for Nanopores

Oliver Beckstein, Philip C. Biggin, Mark S.P. Sansom · The Journal of Physical Chemistry B · 2001 · 296 citations

Engineering, Nanoporous Material, Porous Membrane +16

Structure and Orientation of the Mammalian Antibacterial Peptide Cecropin P1 within Phospholipid Membranes

Ehud Gazit, I.R. Miller, Philip C. Biggin et al. · Journal of Molecular Biology · 1996 · 280 citations

Proteinlipid Interaction, Phospholipid Membranes, Biochemistry +5

Molecular basis for redox control by the human cystine/glutamate antiporter system xc−

Joanne L. Parker, Justin C. Deme, Dimitrios Kolokouris et al. · Nature Communications · 2021 · 219 citations · Full text

Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations

Matteo Aldeghi, Alexander Heifetz, Michael J. Bodkin et al. · Journal of the American Chemical Society · 2016 · 194 citations · Full text

Drug Target, Engineering, Computational Chemistry +17