Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

Marcello D’Amelio, Virve Cavallucci, Silvia Middei, +12

Nature Neuroscience

Synaptic PlasticityAlzheimer's DiseaseMolecular NeuroscienceCaspase-3 TriggersDementia +12

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials

Alberto Ferri, Mauro Cozzolino, Claudia Crosio, +6

Proceedings of the National Academy of Sciences

Molecular BiologySelective RecruitmentMutant Sod1 ProteinsRedox BiologyOxidative Stress +14

Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca²⁺ concentration in transfected neuroblastoma SH‐SY5Y cells

Alberto Ferri, Andrea Battistoni, Laila Famhy, +3

FEBS Letters

Znsod ContentNeurodegenerative DiseasesAmyotrophic Lateral SclerosisMitochondrial FunctionBiochemistry +13

Cysteine 111 Affects Aggregation and Cytotoxicity of Mutant Cu,Zn-superoxide Dismutase Associated with Familial Amyotrophic Lateral Sclerosis

Mauro Cozzolino, Ilaria Amori, Maria Grazia Pesaresi, +3

Journal of Biological Chemistry

The Proinflammatory Action of Microglial P2 Receptors Is Enhanced in SOD1 Models for Amyotrophic Lateral Sclerosis

Nadia D’Ambrosi, Pamela Finocchi, Savina Apolloni, +6

The Journal of Immunology

Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

Manoj K. Jaiswal, Wolf‐Dieter Zech, Miriam Goos, +6

BMC Neuroscience

Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity

Alberto Ferri, Paolo Fiorenzo, Monica Nencini, +6

Human Molecular Genetics

Glutaredoxin 2Mitochondrial DysfunctionMolecular BiologyCell DeathProtein Aggregates +14

Oligomerization of Mutant SOD1 in Mitochondria of Motoneuronal Cells Drives Mitochondrial Damage and Cell Toxicity

Mauro Cozzolino, Maria Grazia Pesaresi, Ilaria Amori, +4

Antioxidants and Redox Signaling

Molecular BiologyCell DeathMitochondrial BiologyRedox BiologyOxidative Stress +15

Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1G93A Mice Predates Disease Onset and Is A Promising Therapeutic Target

Silvia Scaricamazza, I. Salvatori, Giacomo Giacovazzo, +17

iScience

Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine

Simone Beretta, Gessica Sala, Laura Mattavelli, +5

Neurobiology of Disease

Amyotrophic Lateral SclerosisAlzheimer's DiseaseMitochondrial FunctionBiochemistryMitochondrial Dysfunction +10