Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

Yusheng Cai, Huanhuan Zhou, Yinhua Zhu, +11

Cell Research

<i>Scutellaria baicalensis</i> extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease <i>in vitro</i>

Hongbo Liu, Fei Ye, Qi Sun, +7

Journal of Enzyme Inhibition and Medicinal Chemistry

Albumin-Based Nanotheranostic Probe with Hypoxia Alleviating Potentiates Synchronous Multimodal Imaging and Phototherapy for Glioma

Zhenzhen Yang, Yitian Du, Qi Sun, +5

ACS Nano

Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds

Pei Liu, Hongbo Liu, Qi Sun, +5

European Journal of Medicinal Chemistry

N-substituted Isatin CompoundsMedicineAntiviral Drug DevelopmentSars-cov-2 3C-like ProteasePotent Inhibitors +5

Computational strategy for intrinsically disordered protein ligand design leads to the discovery of p53 transactivation domain I binding compounds that activate the p53 pathway

Hao Ruan, Yu Chen, Xiaogang Niu, +8

Chemical Science

Drug TargetEngineeringMolecular BiologyComputational ChemistryComputational Strategy +17

Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease

Qi Sun, Fei Ye, Hao Liang, +7

Signal Transduction and Targeted Therapy

3C-like ProteaseBardoxolone MethylMedicineImmunologyClinical Trials +5

Phototherapy and anti-GITR antibody-based therapy synergistically reinvigorate immunogenic cell death and reject established cancers

Qi Sun, Zhenzhen Yang, Meng Lin, +5

Biomaterials

Photodynamic TherapyMedicineImmunogenic Cell DeathImmunologyImmunoediting +9

A transferable deep learning approach to fast screen potential antiviral drugs against SARS-CoV-2

Shiwei Wang, Qi Sun, Youjun Xu, +2

Briefings in Bioinformatics

Flow Cytometry-Based Binding Assay for GPR40 (FFAR1; Free Fatty Acid Receptor 1)

Takafumi Hara, Akira Hirasawa, Qi Sun, +5

Molecular Pharmacology

<i>Scutellaria baicalensis</i> extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease <i>in vitro</i>

Hongbo Liu, Fei Ye, Qi Sun, +6